Impaired cerebral microvascular endothelial cells integrity due to elevated dopamine in myasthenic model.

ABSTRACT: Myasthenia gravis is an autoimmune disease characterized by pathogenic antibodies that target structures of the neuromuscular junction. However, some patients also experience autonomic dysfunction, anxiety, depression, and other neurological symptoms, suggesting the complex nature of the neurological manifestations. With the aim of explaining the symptoms related to the central nervous system, we utilized a rat model to investigate the impact of dopamine signaling in the central nervous and peripheral circulation. We adopted several screening methods, including western blot, quantitative PCR, mass spectrum technique, immunohistochemistry, immunofluorescence staining, and flow cytometry. In this study, we observed increased and activated dopamine signaling in both the central nervous system

SUBMITTER: Hao Y 

PROVIDER: S-EPMC10765813 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature