Causal relationship between gut microbiota and tuberculosis: a bidirectional two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Growing evidence from observational studies and clinical trials suggests that the gut microbiota is associated with tuberculosis (TB). However, it is unclear whether any causal relationship exists between them and whether causality is bidirectional.

Methods

A bidirectional two-sample Mendelian randomization (MR) analysis was performed. The genome-wide association study (GWAS) summary statistics of gut microbiota were obtained from the MiBioGen consortium, while the GWAS summary statistics of TB and its specific phenotypes [respiratory tuberculosis (RTB) and extrapulmonary tuberculosis (EPTB)] were retrieved from the UK Biobank and the FinnGen consortium. And 195 bacterial taxa from phylum to genus were analyzed. Inverse variance weighted (IVW), MR-Egger regression

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC10765819 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature