Regular use of paracetamol and risk of liver cancer: a prospective cohort study.

ABSTRACT:

Background

Paracetamol induces hepatotoxicity and subsequent liver injury, which may increase the risk of liver cancer, but epidemiological evidence remains unclear. We conducted this study to evaluate the association between paracetamol use and the risk of liver cancer.

Methods

This prospective study included 464,244 participants free of cancer diagnosis from the UK Biobank. Incident liver cancer was identified through linkage to cancer and death registries and the National Health Service Central Register using the International Classification of Diseases (ICD)-10 codes (C22). An overlap-weighted Cox proportional hazards model was utilized to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the risk of liver cancer associated with paracetamol use. The nu

SUBMITTER: Tian L 

PROVIDER: S-EPMC10765829 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature