InterDILI: interpretable prediction of drug-induced liver injury through permutation feature importance and attention mechanism.

ABSTRACT: Safety is one of the important factors constraining the distribution of clinical drugs on the market. Drug-induced liver injury (DILI) is the leading cause of safety problems produced by drug side effects. Therefore, the DILI risk of approved drugs and potential drug candidates should be assessed. Currently, in vivo and in vitro methods are used to test DILI risk, but both methods are labor-intensive, time-consuming, and expensive. To overcome these problems, many in silico methods for DILI prediction have been suggested. Previous studies have shown that DILI prediction models can be utilized as prescreening tools, and they achieved a good performance. However, there are still limitations in interpreting the prediction results. Therefore, this study focused on interpreting the model predic

SUBMITTER: Lee S 

PROVIDER: S-EPMC10765872 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature