Identification of a Notch transcriptomic signature for breast cancer.

ABSTRACT:

Background

Dysregulated Notch signalling contributes to breast cancer development and progression, but validated tools to measure the level of Notch signalling in breast cancer subtypes and in response to systemic therapy are largely lacking. A transcriptomic signature of Notch signalling would be warranted, for example to monitor the effects of future Notch-targeting therapies and to learn whether altered Notch signalling is an off-target effect of current breast cancer therapies. In this report, we have established such a classifier.

Methods

To generate the signature, we first identified Notch-regulated genes from six basal-like breast cancer cell lines subjected to elevated or reduced Notch signalling by culturing on immobilized Notch ligand Jagged1 or blockade of Notch b

SUBMITTER: Braune EB 

PROVIDER: S-EPMC10765899 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature