Randomized controlled trial of remote ischemic preconditioning in children having cardiac surgery.

ABSTRACT:

Background

Children undergoing cardiac surgery are at risk for acute kidney injury (AKI) and cardiac dysfunction. Opportunity exists in protecting end organ function with remote ischemic preconditioning. We hypothesize this intervention lessens kidney and myocardial injury.

Methods

We conducted a randomized, double blind, placebo controlled trial of remote ischemic preconditioning in children undergoing cardiac surgery. Pre-specified end points are change in creatinine, estimated glomerular filtration rate, development of AKI, B-type natriuretic peptide and troponin I at 6, 12, 24, 48, 72 h post separation from bypass.

Results

There were 45 in the treatment and 39 patients in the control group, median age of 3.5 and 3.8 years, respectively. There were no differences b

SUBMITTER: Law YM 

PROVIDER: S-EPMC10765905 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature