Abnormal arginine synthesis confers worse prognosis in patients with middle third gastric cancer.

ABSTRACT:

Background

Gastric cancer at different locations has distinct prognoses and biological behaviors, but the specific mechanism is unclear.

Methods

Non-targeted metabolomics was performed to examine the differential metabolite phenotypes that may be associated with the effects of tumor location on the prognosis of gastric cancer. And silencing of the rate-limiting enzyme to evaluate the effect of abnormal changes in metabolic pathway on the functional biological assays of gastric cancer cells HGC-27 and MKN28.

Results

In a retrospective study of 94 gastric cancer patients, the average survival time of patients with gastric cancer in the middle third of the stomach was significantly lower than that of patients with gastric cancer in other locations (p < 0.05). The middle

SUBMITTER: Hong L 

PROVIDER: S-EPMC10765926 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature