Voltammetric methods for electrochemical characterization and quantification of artemether-based antimalarials.

ABSTRACT: Every year substandard and falsified (SF) artemisinin derivative-based antimalarials are responsible for the loss of 450 000 deaths and billions of GBP. The lack of infrastructure and funds to support pharmaceutical quality control in many low-and-middle-income countries contributes to this problem. This work assesses fitness for purpose of voltammetric methods for identification and quantification of artemether in the presence of excipients. Electrochemical characterization of artemether using cyclic voltammetry shows that the reduction of artemether is chemically irreversible within the potential range of -0.4 V to -1.4 V. A chronocoulometric quantification algorithm for artemether is created and tested with pure artemether, as well as filtered and unfiltered Riamet® tablets. Filtration

SUBMITTER: Hildebrand A 

PROVIDER: S-EPMC10765968 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature