Dynamic tuft cell expansion during gastric metaplasia and dysplasia.

ABSTRACT: Tuft cells are chemosensory cells associated with luminal homeostasis, immune response, and tumorigenesis in the gastrointestinal tract. We aimed to elucidate alterations in tuft cell populations during gastric atrophy and tumorigenesis in humans with correlative comparison to relevant mouse models. Tuft cell distribution was determined in human stomachs from organ donors and in gastric pathologies including Ménétrier's disease, Helicobacter pylori gastritis, intestinal metaplasia (IM), and gastric tumors. Tuft cell populations were examined in Lrig1-Kras^G12D , Mist1-Kras^G12D , and MT-TGFα mice. Tuft cells were evenly distributed throughout the entire normal human stomach, primarily concentrated in the isthmal region in the fundus. Ménétrier's disease stomach showed i

SUBMITTER: Jang B 

PROVIDER: S-EPMC10766036 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature