Successful Autologous Hematopoietic Stem Cell Transplant in Glycine Receptor Antibody-Positive Stiff Person Syndrome.

ABSTRACT:

Background and objectives

To describe a case of glycine receptor (GlyR) antibody-positive stiff person syndrome (SPS) treated with autologous hematopoietic stem cell transplant (aHSCT).

Methods

This was a multicenter collaboration for the treatment of a single patient who underwent aHSCT as part of a clinical trial (NCT00716066). To objectively assess the response to transplantation, several clinical outcome measures were evaluated pretransplant and up to 18 months post-transplant, including modified Rankin Score (mRS), stiffness index, Hauser Ambulation Score (HAS), hypersensitivity index, timed 25-foot walk, and Montreal Cognitive Assessment.

Results

After transplant, the patient achieved sustained clinical improvement evidenced across various clinical scales, inclu

SUBMITTER: Celli SI 

PROVIDER: S-EPMC10766081 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature