Adjunctive posterior wall isolation for the treatment of persistent and longstanding persistent atrial fibrillation (CORNERSTONE AF) trial: Design and rationale.

ABSTRACT:

Background

A left atrial posterior wall isolation (LAPWI) is one of the atrial fibrillation (AF) ablation strategies.

Hypothesis

We hypothesized that an additional empirical LAPWI would increase the freedom from recurrent atrial arrhythmias as compared to standard AF ablation in persistent AF patients.

Methods

The CORNERSTONE AF study is a prospective, randomized, multicenter study investigating patients with AF persisting for >7 days and <3 years undergoing first-time AF ablation. They will be randomized to pulmonary vein isolation (PVI) or PVI + LAPWI in a 1:1 manner. Although PVI can be performed with either radiofrequency catheters or cryoballoons, only radiofrequency catheters will be permitted to achieve LAPWIs. Additional focal ablation targeting non-pulmonary

SUBMITTER: Shigeta T 

PROVIDER: S-EPMC10766127 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature