Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. However, the potential contribution of the primary fibrinolytic protease plasminogen to PDAC disease progression has remained largely undefined. Mice bearing C57Bl/6-derived KPC (KRas^G12D , TRP53^R172H ) tumors displayed evidence of plasmin activity in the form of high plasmin-antiplasmin complexes and high plasmin generation potential relative to mice without tumors. Notably, plasminogen-deficient mice (Plg^- ) had significantly diminished KPC tumor growth in subcutaneous and orthotopic implantation models. Moreover, the metastatic potential of KPC cells was significantly diminished in Plg^- mic

SUBMITTER: Chowdhury NN 

PROVIDER: S-EPMC10766200 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature