Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity.

ABSTRACT: Stroke results in local neural disconnection and brain-wide neuronal network dysfunction leading to neurological deficits. Beyond the hyper-acute phase of ischaemic stroke, there is no clinically-approved pharmacological treatment that alleviates sensorimotor impairments. Functional recovery after stroke involves the formation of new or alternative neuronal circuits including existing neural connections. The type-5 metabotropic glutamate receptor (mGluR5) has been shown to modulate brain plasticity and function and is a therapeutic target in neurological diseases outside of stroke. We investigated whether mGluR5 influences functional recovery and network reorganization rodent models of focal ischaemia. Using multiple behavioural tests, we observed that treatment with negative allosteric mo

SUBMITTER: Hakon J 

PROVIDER: S-EPMC10766240 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature