Transdiagnostic inflexible learning dynamics explain deficits in depression and schizophrenia.

ABSTRACT: Deficits in reward learning are core symptoms across many mental disorders. Recent work suggests that such learning impairments arise by a diminished ability to use reward history to guide behaviour, but the neuro-computational mechanisms through which these impairments emerge remain unclear. Moreover, limited work has taken a transdiagnostic approach to investigate whether the psychological and neural mechanisms that give rise to learning deficits are shared across forms of psychopathology. To provide insight into this issue, we explored probabilistic reward learning in patients diagnosed with major depressive disorder (n = 33) or schizophrenia (n = 24) and 33 matched healthy controls by combining computational modelling and single-trial EEG regression. In our task, participants had to in

SUBMITTER: Kirschner H 

PROVIDER: S-EPMC10766268 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature