Exploring the potential molecular mechanism of Gualou Guizhi decoction in the treatment of rheumatoid arthritis based on network pharmacology and molecular docking.

ABSTRACT:

Background

Traditional Chinese medicine (TCM) has been used in China for a long time and is gradually gaining more and more recognition worldwide. Gualou Guizhi Decoction (GGD) has long been used as a folk medicine for the treatment of rheumatic diseases, but its bioactive components and therapeutic mechanisms are still unclear.

Methods

An integrated approach using network pharmacology and molecular docking and using methotrexate as a positive control drug.

Results

We obtained 157 active ingredients of GGD, 7542 RA disease targets and 49 intersecting targets. GO and KEGG enrichment analysis revealed that their functions were mainly related to cytokine active metal ion binding, enzyme binding and DNA binding, and enriched in TNF signaling pathway, T cell receptor signa

SUBMITTER: Duan Z 

PROVIDER: S-EPMC10766275 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature