Dopamine agonists and risk of lung cancer in patients with restless legs syndrome.

ABSTRACT:

Purpose

To examine the association between long-term use of dopamine agonists (DAs) and the risk of lung cancer in patients with restless legs syndrome (RLS).

Methods

We conducted a retrospective cohort study using Optum Clinformatics® database. We included adults ≥40 years diagnosed with RLS during the study period (1/2006-12/2016). Follow-up started with the first RLS diagnosis and ended on the earliest of: incident diagnosis of lung cancer, end of enrollment in the database or end of the study period. The exposure of interest was cumulative duration of DAs use, measured in a time-varying manner. We constructed a multivariable Cox regression model to estimate HRs and 95% CIs for the association between lung cancer and cumulative durations of DA use, adjusting for potential

SUBMITTER: Hernandez-Con P 

PROVIDER: S-EPMC10766437 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature