Rutin alleviated lipopolysaccharide-induced damage in goat rumen epithelial cells.

ABSTRACT:

Objective

Rutin, also called vitamin P, is a flavonoids from plants. Previous studies have indicated that rutin can alleviate the injury of tissues and cells by inhibiting oxidative stress and ameliorating inflammation. There is no report on the protective effects of rutin on goat rumen epithelial cells (GRECs) at present. Hence, we investigated whether rutin can alleviate lipopolysaccharide (LPS)-induced damage in GRECs.

Methods

GRECs were cultured in basal medium or basal medium containing 1 μg/mL LPS, or 1 μg/mL LPS and 20 μg/mL rutin. Six replicates were performed for each group. After 3-h culture, the GRECs were harvested to detect the relevant parameters.

Results

Rutin significantly enhanced the cell activity (p<0.05) and transepithelial electrical resistance (T

SUBMITTER: Zhan J 

PROVIDER: S-EPMC10766485 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature