Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans.

ABSTRACT: Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role of ECM composition changes in healthy aging remains unclear. Here we perform proteomics and in-vivo monitoring to systematically investigate ECM composition (matreotype) during aging in C. elegans revealing three distinct collagen dynamics. Longevity interventions slow age-related collagen stiffening and prolong the expression of collagens that are turned over. These prolonged collagen dynamics are mediated by a mechanical feedback loop of hemidesmosome-containing structures that span from the exoskeletal ECM through the hypodermis, basement membrane ECM

SUBMITTER: Teuscher AC 

PROVIDER: S-EPMC10766642 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature