Preclinical research in paclitaxel-induced neuropathic pain: a systematic review.

ABSTRACT:

Introduction

Chemotherapy-induced peripheral neuropathy (CIPN) is a common consequence of cancer treatment and pain is a frequent complaint of the patients. Paclitaxel, a cytostatic drug, generates a well-described peripheral nerve injury and neuroinflammation, which may be experimentally mimicked in animal models. We conducted a systematic review analyzing the experimental design, reporting and mechanisms underlying paclitaxel-induced neuropathy in the included studies to establish the perspectives of translation of the current literature in models of CIPN.

Methods

We elected studies published in Pubmed and Scopus between 1 January 2018 and 3 December 2022.

Results

According to a defined mesh of keywords searched, and after applying exclusion and inclusion criteria,

SUBMITTER: Bacalhau C 

PROVIDER: S-EPMC10766764 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature