B-cell-specific MhcII regulates microbiota composition in a primarily IgA-independent manner.

ABSTRACT:

Background

The expression of major histocompatibility complex class II (MhcII) molecules on B cells is required for the development of germinal centers (GCs) in lymphoid follicles; the primary sites for the generation of T-cell-dependent (TD) antibody responses. Peyer's patches (PPs) are secondary lymphoid tissues (SLOs) in the small intestine (SI) that give rise to high-affinity, TD antibodies (mainly immunoglobulin A (IgA)) generated against the microbiota. While several studies have demonstrated that MhcII antigen presentation by other immune cells coordinate TD IgA responses and regulate microbiota composition, whether or not B-cell-specific MhcII influences gut microbial ecology is unknown.

Methods

Here, we developed a novel Rag1 ^-/-

SUBMITTER: Roland MM 

PROVIDER: S-EPMC10766766 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature