Serum IL-17 and TNFα as prognostic biomarkers in systemic sclerosis patients: a prospective study.

ABSTRACT: Recent reports have demonstrated that endothelial injury is critical in the pathogenesis of systemic sclerosis (SSc) and is associated with increased levels of circulating inflammatory biomarkers. This study aims to analyze the serum concentrations of selected cytokines and evaluate their relationship with SSc clinics and the long-term course of the disease. This study included 43 SSc patients and 24 matched healthy controls. In both groups, we measured serum levels of inflammatory cytokines related to the inflammatory response, such as tumor necrosis factor (TNF)α, interferon (IFN)γ, interleukin (IL)-4, IL-6, IL-10, and IL-17, and fibroblast activation protein (FAP). Additionally, in SSc patients, we evaluated the presence of four single nucleotide polymorphisms (SNPs) located in the prom

SUBMITTER: Kosalka-Wegiel J 

PROVIDER: S-EPMC10766799 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature