Comparing sputum microbiota characteristics between severe and critically ill influenza patients.

ABSTRACT:

Background

Currently, limited attention has been directed toward utilizing clinical cohorts as a starting point to elucidate alterations in the lower respiratory tract (LRT) microbiota following influenza A virus (IAV) infection.

Objectives

Our objective was to undertake a comparative analysis of the diversity and composition of sputum microbiota in individuals afflicted by severe and critically ill influenza patients.

Methods

Sputum specimens were procured from patients diagnosed with IAV infection for the purpose of profiling the microbiota using 16S-rDNA sequencing. To ascertain taxonomic differences between the severe and critically ill influenza cohorts, we leveraged Linear Discriminant Analysis Effect Size (LEfSe). Additionally, Spearman correlation analysis was

SUBMITTER: Gu Z 

PROVIDER: S-EPMC10766813 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature