The metaproteome of the gut microbiota in pediatric patients affected by COVID-19.

ABSTRACT:

Introduction

The gut microbiota (GM) play a significant role in the infectivity and severity of COVID-19 infection. However, the available literature primarily focuses on adult patients and it is known that the microbiota undergoes changes throughout the lifespan, with significant alterations occurring during infancy and subsequently stabilizing during adulthood. Moreover, children have exhibited milder symptoms of COVID-19 disease, which has been associated with the abundance of certain protective bacteria. Here, we examine the metaproteome of pediatric patients to uncover the biological mechanisms that underlie this protective effect of the GM.

Methods

We performed nanoliquid chromatography coupled with tandem mass spectrometry on a high resolution analytical platform, res

SUBMITTER: Marzano V 

PROVIDER: S-EPMC10766818 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature