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Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss.

ABSTRACT: Oral diseases exhibit a significant association with metabolic syndrome, including dyslipidemia. However, direct evidence supporting this relationship is lacking, and the involvement of cholesterol metabolism in the pathogenesis of periodontitis (PD) has yet to be determined. In this study, we showed that high cholesterol caused periodontal inflammation in mice. Cholesterol homeostasis in human gingival fibroblasts was disrupted by enhanced uptake through C-X-C motif chemokine ligand 16 (CXCL16), upregulation of cholesterol hydroxylase (CH25H), and the production of 25-hydroxycholesterol (an oxysterol metabolite of CH25H). Retinoid-related orphan receptor α (RORα) mediated the transcriptional upregulation of inflammatory mediators; consequently, PD pathogenesis mechanisms, including alveolar bone loss, were stimulated. Our collective data provided direct evidence that hyperlipidemia is a risk factor for PD and supported that inhibition of the CXCL16-CH25H-RORα axis is a potential treatment mechanism for PD as a systemic disorder manifestation.

SUBMITTER: Tran TT

PROVIDER: S-EPMC10767058 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss.

Tran Thanh-Tam TT Lee Gyuseok G Huh Yun Hyun YH Chung Ki-Ho KH Lee Sun Young SY Park Ka Hyon KH Kwon Seung Hee SH Kook Min-Suk MS Chun Jang-Soo JS Koh Jeong-Tae JT Ryu Je-Hwang JH

Experimental & molecular medicine 20231201 12

Oral diseases exhibit a significant association with metabolic syndrome, including dyslipidemia. However, direct evidence supporting this relationship is lacking, and the involvement of cholesterol metabolism in the pathogenesis of periodontitis (PD) has yet to be determined. In this study, we showed that high cholesterol caused periodontal inflammation in mice. Cholesterol homeostasis in human gingival fibroblasts was disrupted by enhanced uptake through C-X-C motif chemokine ligand 16 (CXCL16) ...[more]

PMID: 38036731

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Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss.

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Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss.

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