The moderating effect of fluid overload on the relationship between the augmentation index and left ventricular diastolic function in patients with CKD.

ABSTRACT: Increased vascular stiffness, fluid overload, and left ventricular diastolic dysfunction (LVDD) are common in patients with chronic kidney disease (CKD). We investigated the potential moderating effect of volume status in the relationship between arterial stiffness and left ventricular (LV) diastolic function in non-dialysis patients with stage 5 CKD. The radial augmentation index at a heart rate of 75 beats/min (rAIx75), overhydration/extracellular water (OH/ECW), and E/e´ ratio were concurrently measured in 152 consecutive patients. Each of these parameters reflects the status of vascular stiffness, fluid balance, and LV diastolic function, respectively. Hierarchical regression analysis demonstrated a significant interaction effect of OH/ECW for all patients (P = 0.015), even after contr

SUBMITTER: Han BG 

PROVIDER: S-EPMC10767097 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature