Diurnal retinal and choroidal gene expression patterns support a role for circadian biology in myopia pathogenesis.

ABSTRACT: The prevalence of myopia (nearsightedness) is increasing to alarming levels, but its etiology remains poorly understood. Because both laboratory and clinical findings suggest an etiologic role for circadian rhythms in myopia development, we assayed gene expression by RNA-Seq in retina and choroid at the onset of unilateral experimental myopia in chick, isolating tissues every 4 h during a single 24-h period from myopic and contralateral control eyes. Occluded versus open eye gene expression differences varied considerably over the 24-h sampling period, with some occurring at multiple times of day but with others showing differences at only a single investigated timepoint. Some of the genes identified in retina or choroid of chick myopia were previously identified as candidate genes for com

SUBMITTER: Stone RA 

PROVIDER: S-EPMC10767138 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature