The association of systemic inflammatory biomarkers with non-alcoholic fatty liver disease: a large population-based cross-sectional study.

ABSTRACT:

Purpose

The aim of this study was to explore the relationship between non-alcoholic fatty liver disease (NAFLD) and the two blood inflammatory markers including the systemic immune-inflammation (SII) index, and the system inflammation response index (SIRI).

Methods

The National Health and Nutrition Examination Survey data between the year of 2017-2018 was used for this cross-sectional study. In order to analyze the association of SII index, and SIRI and risk of NAFLD, we used multivariable logistic regression models, restricted cubic spline (RCS) plot, and subgroup analysis to analyze the data.

Results

In total, there were 1,199 individuals who participated in the survey. As shown by the RCS plot, SII index, and SIRI were linked with NAFLD risk in a U-shaped pattern.

SUBMITTER: Sun W 

PROVIDER: S-EPMC10767190 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature