A novel electrospun polylactic acid silkworm fibroin mesh for abdominal wall hernia repair.

ABSTRACT:

Objective

Abdominal wall hernias are common abdominal diseases, and effective hernia repair is challenging. In clinical practice, synthetic meshes are widely applied for repairing abdominal wall hernias. However, postoperative complications, such as inflammation and adhesion, are prevalent. Although biological meshes can solve this problem to a certain extent, they face the problems of heterogeneity, rapid degradation rate, ordinary mechanical properties, and high-cost. Here, a novel electrospinning mesh composed of polylactic acid and silk fibroin (PLA-SF) for repairing abdominal wall hernias was manufactured with good physical properties, biocompatibility and low production cost.

Materials and methods

FTIR and EDS were used to demonstrate that the PLA-SF mesh was successfu

SUBMITTER: Wang X 

PROVIDER: S-EPMC10767193 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature