ELK3-ID4 axis governs the metastatic features of triple negative breast cancer.

ABSTRACT:

Purpose

Cancer cell metastasis is a multistep process, and the mechanism underlying extravasation remains unclear. ELK3 is a transcription factor that plays a crucial role in regulating various cellular processes, including cancer metastasis. Based on the finding that ELK3 promotes the metastasis of triple-negative breast cancer (TNBC), we investigated whether ELK3 regulates the extravasation of TNBC by forming the ELK3-ID4 axis. ID4 functions as a transcriptional regulator that interacts with other transcription factors, inhibiting their activity and subsequently influencing various biological processes associated with cell differentiation, survival, growth, and metastasis.

Methods

We assessed the correlation between the expression of ELK3 and that of ID4 in TNBCs using bio

SUBMITTER: Choi JH 

PROVIDER: S-EPMC10767247 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature