Transient receptor potential channels as predictive marker and potential indicator of chemoresistance in colon cancer.

ABSTRACT: Transient receptor potential (TRP) channels are strongly associated with colon cancer development and progression. This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature, with further validation of signature in real world samples from our hospital treated patient samples. Kaplan-Meier (K-M) survival analysis and receiver operating characteristic (ROC) curves were employed to evaluate this gene signature's predictive accuracy and robustness in both training and testing cohorts, respectively. Additionally, the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature's immune infiltration landscape and underlying functional implications. The support vect

SUBMITTER: Hu W 

PROVIDER: S-EPMC10767253 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature