Denture use and risk for cardiometabolic disease: observational and Mendelian randomization analyses.

ABSTRACT:

Aims

Denture use may potentially increase the risk of cardiometabolic diseases (CMDs), but the casual relevance and strength of the associations are currently unknown.

Methods and results

A total of 495 938 participants from the UK Biobank were included in the observational analyses. Linkage disequilibrium score (LDSC) regression and Mendelian randomization analyses were employed to estimate genetic correlation and the associations between the genetic liability for denture use with coronary artery disease, myocardial infarction, heart failure (HF), any stroke (AS), ischaemic stroke, haemorrhagic stroke, type 2 diabetes (T2D), and related clinical risk factors. In observational analysis, denture use was associated with 14-25% higher risks of various CMDs. The LDSC analysis fo

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10767255 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature