Heterogeneity of gut microbiome compositions in the third decade of life in Japanese women: insights from a comparative analysis.

ABSTRACT: The reasons for sex-associated gut microbiota differences have not been determined, and although sex hormones, diet, and other factors are considered to contribute to them, many of these factors are age related. To shed light on this complex interplay, our study aimed to investigate and compare the gut microbial compositions of males and females across a broad range of ages, aiming to identify sex-associated disparities and potential causal factors. Our study encompassed a comprehensive analysis of gut microbiota data obtained from 444 Japanese individuals, ranging from newborns to centenarians, sourced from the DNA Data Bank of Japan. We categorized the subjects into 13 distinct age groups and examined their relative microbial abundances, as well as alpha and beta diversities, in relation

SUBMITTER: LE TM 

PROVIDER: S-EPMC10767325 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature