Comprehensive analysis reveals dual biological function roles of EpCAM in kidney renal clear cell carcinoma.

ABSTRACT:

Background

Epithelial cell adhesion molecule (EpCAM), a well-established marker for circulating tumor cells, plays a crucial role in the complex process of cancer metastasis. The primary objective of this investigation is to study EpCAM expression in pan-cancer and elucidate its significance in the context of kidney renal clear cell carcinoma (KIRC).

Methods

Data obtained from the public database was harnessed for the comprehensive assessment of the EpCAM expression levels and prognostic and clinicopathological correlations in thirty-three types of cancer. EpCAM was validated in our own KIRC sequencing and immunohistochemical cohorts. Subsequently, an in-depth exploration was conducted to scrutinize the interrelationship between EpCAM and various facets, including immune cel

SUBMITTER: Chen M 

PROVIDER: S-EPMC10767389 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature