Hypertension in NF1: A closer look at the primacy of essential hypertension versus secondary causes.

ABSTRACT:

Background

We aimed to analyze hypertension in neurofibromatosis type 1 (NF1) in a Finnish population-based cohort in 1996-2014.

Methods

A cohort of 1365 individuals with confirmed NF1 was compared with a control cohort of 13,923 individuals matched for age, sex, and area of residence. Diagnoses of hypertension were retrieved from the Finnish Care Register for Health Care. These registered data were separately analyzed for secondary and essential hypertension. Purchases of antihypertensive drugs were queried from the Finnish Register of Reimbursed Drug Purchases.

Results

We identified 115 NF1 patients with hospital diagnosis of hypertension. Our findings revealed a hazard ratio (HR) of 1.64 (95% CI 1.34-2.00, p < 0.001) in NF1 versus controls. NF1 patients presented w

SUBMITTER: Loponen N 

PROVIDER: S-EPMC10767585 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature