Rates of Occult Invasive Disease in Patients With Biopsy-Proven Oral Cavity Squamous Cell Carcinoma in Situ.

ABSTRACT:

Importance

The likelihood that an oral cavity lesion harbors occult invasive disease after biopsy demonstrating carcinoma in situ (CIS) is unknown. While de-escalated treatment strategies may be appealing in the setting of CIS, knowing whether occult invasive disease may be present and its association with survival outcomes would lead to more informed management decisions.

Objective

To evaluate rate of occult invasive disease and clinical outcomes in patients with oral cavity CIS.

Design, setting, and participants

This was a retrospective population-based cohort study using the National Cancer Database and included adults with biopsy-proven oral cavity CIS as the first diagnosis of cancer between 2004 and 2020. Data were analyzed from October 10, 2022, to June 25, 202

SUBMITTER: Cooper DJ 

PROVIDER: S-EPMC10767638 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature