Alzheimer Disease Treatment With Acetylcholinesterase Inhibitors and Incident Age-Related Macular Degeneration.

ABSTRACT:

Importance

Age-related macular degeneration (AMD) is a serious and common ophthalmologic disorder that is hypothesized to result, in part, from inflammatory reactions in the macula. Alzheimer disease (AD) treatment, acetylcholinesterase inhibitors (AChEIs), have anti-inflammatory effects and it remains unclear if they modify the risk of AMD.

Objective

To investigate the association between AChEI medications and the incidence of AMD.

Design, setting, and participants

This propensity score-matched retrospective cohort study took place at health care facilities within the US Department of Veterans Affairs (VA) health care system from January 2000 through September 2023. Participants included patients diagnosed with AD between ages 55 and 80 years with no preexisting diag

SUBMITTER: Sutton SS 

PROVIDER: S-EPMC10767642 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature