RvE1 Promotes Axin2+ Cell Regeneration and Reduces Bacterial Invasion.

ABSTRACT: Vital pulp therapy and root canal therapy (RCT) are the dominant treatment for irreversible pulpitis. While the success rate of these procedures is favorable, they have some limitations. For instance, RCT leads to removing significant dentin in the coronal third of the tooth that increases root-fracture risk, which forces tooth removal. The ideal therapeutic goal is dental pulp regeneration, which is not achievable with RCT. Specialized proresolving mediators (SPMs) are well known for inflammatory resolution. The resolution of inflammation and tissue restoration or regeneration is a dynamic and continuous process. SPMs not only have potent immune-modulating functions but also effectively promote tissue homeostasis and regeneration. Resolvins have been shown to promote dental pulp regenerat

SUBMITTER: Wu YC 

PROVIDER: S-EPMC10767698 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature