JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles.

ABSTRACT: JASPAR (https://jaspar.elixir.no/) is a widely-used open-access database presenting manually curated high-quality and non-redundant DNA-binding profiles for transcription factors (TFs) across taxa. In this 10th release and 20th-anniversary update, the CORE collection has expanded with 329 new profiles. We updated three existing profiles and provided orthogonal support for 72 profiles from the previous release's UNVALIDATED collection. Altogether, the JASPAR 2024 update provides a 20% increase in CORE profiles from the previous release. A trimming algorithm enhanced profiles by removing low information content flanking base pairs, which were likely uninformative (within the capacity of the PFM models) for TFBS predictions and modelling TF-DNA interactions. This release includes enhanced met

SUBMITTER: Rauluseviciute I 

PROVIDER: S-EPMC10767809 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature