M2OR: a database of olfactory receptor-odorant pairs for understanding the molecular mechanisms of olfaction.

ABSTRACT: Mammalian sense of smell is triggered by interaction between odorant molecules and a class of proteins, called olfactory receptors (ORs). These receptors, expressed at the surface of olfactory sensory neurons, encode myriad of distinct odors via a sophisticated activation pattern. However, determining the molecular recognition spectrum of ORs remains a major challenge. The Molecule to Olfactory Receptor database (M2OR, https://m2or.chemsensim.fr/) provides curated data that allows an easy exploration of the current state of the research on OR-molecule interaction. We have gathered a database of 75,050 bioassay experiments for 51 395 distinct OR-molecule pairs. Drawn from published literature and public databases, M2OR contains information about OR responses to molecules and their mixtures,

SUBMITTER: Lalis M 

PROVIDER: S-EPMC10767820 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature