HOCOMOCO in 2024: a rebuild of the curated collection of binding models for human and mouse transcription factors.

ABSTRACT: We present a major update of the HOCOMOCO collection that provides DNA binding specificity patterns of 949 human transcription factors and 720 mouse orthologs. To make this release, we performed motif discovery in peak sets that originated from 14 183 ChIP-Seq experiments and reads from 2554 HT-SELEX experiments yielding more than 400 thousand candidate motifs. The candidate motifs were annotated according to their similarity to known motifs and the hierarchy of DNA-binding domains of the respective transcription factors. Next, the motifs underwent human expert curation to stratify distinct motif subtypes and remove non-informative patterns and common artifacts. Finally, the curated subset of 100 thousand motifs was supplied to the automated benchmarking to select the best-performing motif

SUBMITTER: Vorontsov IE 

PROVIDER: S-EPMC10767914 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature