MethMotif.Org 2024: a database integrating context-specific transcription factor-binding motifs with DNA methylation patterns.

ABSTRACT: MethMotif (https://methmotif.org) is a publicly available database that provides a comprehensive repository of transcription factor (TF)-binding profiles, enriched with DNA methylation patterns. In this release, we have enhanced the platform, expanding our initial collection to over 700 position weight matrices (PWM), all of which include DNA methylation profiles. One of the key advancements in this release is the segregation of TF-binding motifs based on their cofactors and DNA methylation status. We have previously demonstrated that gene ontology (GO) enriched terms associated with TF target genes may differ based on their association with alternative cofactors and DNA methylation status. MethMotif provides precomputed GO annotations for each human TF of interest, as well as for TF-co-TF

SUBMITTER: Dyer M 

PROVIDER: S-EPMC10767921 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature