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STAB2: an updated spatio-temporal cell atlas of the human and mouse brain.


ABSTRACT: The brain is constituted of heterogeneous types of neuronal and non-neuronal cells, which are organized into distinct anatomical regions, and show precise regulation of gene expression during development, aging and function. In the current database release, STAB2 provides a systematic cellular map of the human and mouse brain by integrating recently published large-scale single-cell and single-nucleus RNA-sequencing datasets from diverse regions and across lifespan. We applied a hierarchical strategy of unsupervised clustering on the integrated single-cell transcriptomic datasets to precisely annotate the cell types and subtypes in the human and mouse brain. Currently, STAB2 includes 71 and 61 different cell subtypes defined in the human and mouse brain, respectively. It covers 63 subregions and 15 developmental stages of human brain, and 38 subregions and 30 developmental stages of mouse brain, generating a comprehensive atlas for exploring spatiotemporal transcriptomic dynamics in the mammalian brain. We also augmented web interfaces for querying and visualizing the gene expression in specific cell types. STAB2 is freely available at https://mai.fudan.edu.cn/stab2.

SUBMITTER: Yang YT 

PROVIDER: S-EPMC10767951 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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STAB2: an updated spatio-temporal cell atlas of the human and mouse brain.

Yang Yucheng T YT   Gan Ziquan Z   Zhang Jinglong J   Zhao Xingzhong X   Yang Yifan Y   Han Shuwen S   Wu Wei W   Zhao Xing-Ming XM  

Nucleic acids research 20240101 D1


The brain is constituted of heterogeneous types of neuronal and non-neuronal cells, which are organized into distinct anatomical regions, and show precise regulation of gene expression during development, aging and function. In the current database release, STAB2 provides a systematic cellular map of the human and mouse brain by integrating recently published large-scale single-cell and single-nucleus RNA-sequencing datasets from diverse regions and across lifespan. We applied a hierarchical str  ...[more]

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