MHapBrowser: a comprehensive database for visualization and analysis of DNA methylation haplotypes.

ABSTRACT: DNA methylation acts as a vital epigenetic regulatory mechanism involved in controlling gene expression. Advances in sequencing technologies have enabled characterization of methylation patterns at single-base resolution using bisulfite sequencing approaches. However, existing methylation databases have primarily focused on mean methylation levels, overlooking phased methylation patterns. The methylation status of CpGs on individual sequencing reads represents discrete DNA methylation haplotypes (mHaps). Here, we present mHapBrowser, a comprehensive database for visualizing and analyzing mHaps. We systematically processed data of diverse tissues in human, mouse and rat from public repositories, generating mHap format files for 6366 samples. mHapBrowser enables users to visualize eight mHap

SUBMITTER: Hong Y 

PROVIDER: S-EPMC10767976 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature