Association between pre-ICU statin use and ARDS mortality in the MIMIC-IV database: a cohort study.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is a severe condition associated with high morbidity, mortality, and healthcare costs. Despite extensive research, treatment options for ARDS are suboptimal.

Methods

This study encompassed patients diagnosed with ARDS from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. Pre-intensive care unit (ICU) statin use was assessed as the exposure variable. Kaplan-Meier survival analysis was conducted to evaluate mortality at 30 and 90 days. Adjusted multivariable Cox models were utilized to estimate hazard ratios. Subgroup analyses and propensity score-matching (PSM) were undertaken for further validation.

Results

Our study comprised 10,042 participants diagnosed with ARDS, with an average age of 61

SUBMITTER: Mao H 

PROVIDER: S-EPMC10768014 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature