Genetically predicted basal metabolic rate and venous thromboembolism risk: a Mendelian randomization study.

ABSTRACT:

Background

Basal metabolic rate (BMR) is the minimum amount of energy needed by the body to carry out essential physiological functions. The goal of this study was to evaluate whether BMR causally influences venous thromboembolism (VTE) and its subtypes in European individuals.

Methods

A two-sample Mendelian randomization (MR) was performed. Within a genome-wide association study (GWAS) involving 454,874 people, genetic variants were chosen as instrumental variables based on their significant associations (p < 5 × 10^-8) with BMR and their limited linkage disequilibrium (r² < 0.001). The FinnGen project served as sources for summary statistics of VTE, encompassing different subtypes.

Results

Using the multiplicative random-effect inv

SUBMITTER: Huang J 

PROVIDER: S-EPMC10768029 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature