Peripheral immune markers and amyotrophic lateral sclerosis: a Mendelian randomization study.

ABSTRACT:

Introduction

The peripheral immune system changes in amyotrophic lateral sclerosis (ALS), but the causal relationship between the two is still controversial.

Methods

In this study, we aimed to estimate the causal relationship between peripheral immune markers and ALS using a two-sample Mendelian randomization method. Genome-wide association study (GWAS) data on peripheral blood immune traits from European populations were used for exposure, and ALS summary statistics were used as the outcome. The causal relationship was evaluated by inverse variance weighting, MR-Egger, and weighted median methods and verified by multiple sensitivity analysis.

Results

We found that the increase of one standard deviation of lymphocyte count is related to reducing ALS risk. CD3 on effec

SUBMITTER: Hu Z 

PROVIDER: S-EPMC10768049 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature