Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity.

ABSTRACT:

Background

The observation that the intestinal microbiota is  central in the development of IBD suggests that dietary fiber, the microbiota's primary source of nourishment, could play a central role in these diseases. Accordingly, enriching diets with specific soluble fibers remodels microbiota and modulates colitis sensitivity. In humans, a recent study suggests that the microbiota of select IBD patients might influence the impacts they would experience upon fiber exposure. We sought here to define the extent to which individual microbiotas varied in their responsiveness to purified soluble fiber inulin and psyllium. Moreover, the extent to which such variance might impact proneness to colitis.

Results

We observed a high level of inter-individual variation in microbiota res

SUBMITTER: Bonazzi E 

PROVIDER: S-EPMC10768099 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature