Open Genes-a new comprehensive database of human genes associated with aging and longevity.

ABSTRACT: The Open Genes database was created to enhance and simplify the search for potential aging therapy targets. We collected data on 2402 genes associated with aging and developed convenient tools for searching and comparing gene features. A comprehensive description of genes has been provided, including lifespan-extending interventions, age-related changes, longevity associations, gene evolution, associations with diseases and hallmarks of aging, and functions of gene products. For each experiment, we presented the necessary structured data for evaluating the experiment's quality and interpreting the study's findings. Our goal was to stay objective and precise while connecting a particular gene to human aging. We distinguished six types of studies and 12 criteria for adding genes to our datab

SUBMITTER: Rafikova E 

PROVIDER: S-EPMC10768108 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature