The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement.

ABSTRACT:

Background

The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement.

Methods

Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2^-/-) group. Orthodontic tooth movement (OTM) was induced by applying a nickel-titanium coil spring between the maxillary first molar and the central incisors. There are three subgroups within the WT groups (0, 7 and 14 days) and the CB2^-/- groups (0, 7 and 14 days). 0-day groups without force application. Tooth displacement, alveolar bone mass and alveolar bone volume were assessed by micro-CT on 0, 7 and 14 days, and the number of osteoclasts was quantified by tartrate-resistant acid phosphatase (TRAP) staining.

SUBMITTER: Fan DY 

PROVIDER: S-EPMC10768142 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature