Chronic COVID-19 infection in an immunosuppressed patient shows changes in lineage over time: a case report.

ABSTRACT:

Background

The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 virus, emerged in late 2019 and spready globally. Many effects of infection with this pathogen are still unknown, with both chronic and repeated COVID-19 infection producing novel pathologies.

Case presentation

An immunocompromised patient presented with chronic COVID-19 infection. The patient had history of Hodgkin's lymphoma, treated with chemotherapy and stem cell transplant. During the course of their treatment, eleven respiratory samples from the patient were analyzed by whole-genome sequencing followed by lineage identification. Whole-genome sequencing of the virus present in the patient over time revealed that the patient at various timepoints harboured three different line

SUBMITTER: Baker SJC 

PROVIDER: S-EPMC10768205 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature